Mark Worthington first played in the national team in 2005 and then went on to compete in the green and gold at the 2006 Commonwealth Games, 2006 World Championships, 2008 Beijing Olympics and 2010 World Championships. Worthington debuted in the NBL for the Sydney Kings in 2006 and was named NBL Rookie of the Year.
He went on to compete at his second Olympic competition at the London 2012 Games. With Australia losing their opening two preliminary matches to Brazil and Spain, they went on to defeat China, hosts Great Britain and Russia to set up a quarter-final match against the USA. The Australians went down 119-86 to the eventual gold medallists to finish seventh.